Decarboxylative biaryl synthesis in a continuous flow reactor.
نویسندگان
چکیده
A practical protocol was developed that allows performing decarboxylative cross-coupling reactions in continuous flow reactors. Various biaryls were thus synthesized from aromatic carboxylic acids and aryl triflates using a Cu/Pd-catalyst system.
منابع مشابه
Ni-Catalyzed Electrochemical Decarboxylative C–C Couplings in Batch and Continuous Flow
An electrochemically driven, nickel-catalyzed reductive coupling of N-hydroxyphthalimide esters with aryl halides is reported. The reaction proceeds under mild conditions in a divided electrochemical cell and employs a tertiary amine as the reductant. This decarboxylative C(sp3)-C(sp2) bond-forming transformation exhibits excellent substrate generality and functional group compatibility. An ope...
متن کاملPerformance of Biological hydrogen Production Process from Synthesis Gas, Mass Transfer in Batch and Continuous Bioreactors
Biological hydrogen production by anaerobic bacterium, Rhodospirillum rubrum was studied in batch and continuous bioreactors using synthesis gas (CO) as substrate. The systems were operated at ambient temperature and pressure. Correlations available in the literature were used to estimate the gas-liquid mass transfer coefficients (KLa) in batch reactor. Based on experimental results for the con...
متن کاملRecent Progress in Decarboxylative Oxidative Cross‐Coupling for Biaryl Synthesis
The beginning of the 21st century has seen tremendous growth in the field of decarboxylative activation. Benzoic acid derivatives are now recognised as atom-economic alternatives to traditional cross-coupling partners, and they also benefit from being inexpensive, readily available and shelf-stable reagents. In this microreview we discuss recent developments in the coupling of benzoic acid deri...
متن کاملDecarboxylative Palladium(II)-Catalyzed Synthesis of Aryl Amidines from Aryl Carboxylic Acids: Development and Mechanistic Investigation
A fast and convenient synthesis of aryl amidines starting from carboxylic acids and cyanamides is reported. The reaction was achieved by palladium(II)-catalysis in a one-step microwave protocol using [Pd(O2 CCF3 )2 ], 6-methyl-2,2'-bipyridyl and trifluoroacetic acid (TFA) in N-methylpyrrolidinone (NMP), providing the corresponding aryl amidines in moderate to excellent yields. The protocol is v...
متن کاملCitronellyl Butyrate Synthesis in Non-Conventional Media Using Packed-Bed Immobilized Candida Rugosa Lipase Reactor
The synthesis of citronellyl butyrate by direct esterification reaction catalyzed by immobilized lipase from Candida rugosa was studied in a continuous packed bed reactor using n-hexane as organic solvent. Parameters such as residence time, temperature, and pH were examined. The optimum conversion was obtained at a flow rate of 1 ml/min (residence time 8 min), temperature of 50 °C, and pH 7.5. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Chemical communications
دوره 47 12 شماره
صفحات -
تاریخ انتشار 2011